PittsburghはJeff Reedの18ヤードFGで先制し、第2QにGary Russellの1ヤードTDで加点。ArizonaもKurt WarnerからBen Patrickへの1ヤードTDで反撃したが、前半終了間際にJames Harrisonが100ヤードのインターセプトリターンTDを決め、17-7で折り返した。
第3QにReedがFGを追加し20-7とリードを広げるが、第4QにArizonaが猛反撃。WarnerからLarry Fitzgeraldへの2本のTD、特に残り2分47秒の64ヤードTDで23-20と逆転する。だがPittsburghも土壇場で応じ、残り35秒、Ben RoethlisbergerからSantonio Holmesへの6ヤードTDをコーナーでつま先立ちのキャッチで決め切り、27-23と再逆転。最後はLaMarr WoodleyのストリップサックでArizonaの反撃を断ち切った。Warnerは377ヤード3TD (1INT)と気を吐いたが、Steelersが27-23で競り勝ち、球団6度目のSuper Bowl制覇を果たした。
9キャッチ131ヤードでチーム最多の受け球を記録し、残り35秒には土壇場でコーナーへのつま先立ちキャッチを決めて決勝TDを奪った。Arizonaの終盤の逆転劇に応じ、Steelers6度目のタイトルを呼び込んでMVPに選ばれた。
(Shotgun) K.Warner pass short middle intended for A.Boldin INTERCEPTED by J.Harrison at PIT 0. J.Harrison for 100 yards, TOUCHDOWN. Super Bowl Record, longest interception return yards. Penalty on E.Brown, Face Mask (15 Yards), declined. The Replay Assistant challenged the runner broke the plane ruling, and the play was Upheld. Drive-ending interception. Score after play: PIT 17, ARI 7.
(Shotgun) K.Warner pass short middle to L.Fitzgerald for 64 yards, TOUCHDOWN. Touchdown swings the leverage immediately. Score after play: PIT 20, ARI 23.
(Shotgun) B.Roethlisberger pass short right to S.Holmes for 6 yards, TOUCHDOWN. The Replay Assistant challenged the pass completion ruling, and the play was Upheld. Touchdown swings the leverage immediately. Score after play: PIT 27, ARI 23.
(Shotgun) K.Warner sacked at PIT 49 for -5 yards (L.Woodley). FUMBLES (L.Woodley), RECOVERED by B.Keisel at PIT 43. B.Keisel to PIT 43 for no gain (L.Brown). PENALTY on L.Woodley, Unsportsmanlike Conduct, 14 yards, enforced at PIT 43. Turnover flips the possession. Score after play: PIT 27, ARI 23.
(No Huddle) B.Roethlisberger pass short middle intended for S.Holmes INTERCEPTED by K.Dansby (B.Robinson) at PIT 33. K.Dansby to PIT 34 for -1 yards (M.Moore). Drive-ending interception. Score after play: PIT 10, ARI 7.