49ersは第1QにMac JonesからLuke Farrellへの11ヤードTDで先制し、第2QにはEddy PineiroのFGで9-0。New OrleansはSpencer RattlerからJuwan JohnsonへのTDで2点差まで迫ったが、前半終了間際にJonesがChristian McCaffreyへ7ヤードTDを通し、San Franciscoが16-7で折り返す。
後半、Saintsは追い上げを見せてRattlerからRashid ShaheedへのTDで16-14まで迫るも、Fred WarnerがAlvin Kamaraからフォースファンブルでボールを奪い反撃の流れを断たれる。第4QにはJonesからJauan Jenningsへの42ヤードTDで26-14とし試合は決定的に。New OrleansもDevaughn VeleのTDで5点差まで詰めたが、最後は届かなかった。Jonesが279ヤード3TD (0INT)、Rattlerが3TD (0INT)と両QBが活躍を見せるも、守備の一撃が差となった。
随所で見せた好守備に加え、追い上げられた後半に値千金のフォースファンブルを奪い、試合の流れを一人で引き戻した。
S.Rattler pass short right to A.Kamara to SF 29 for 1 yard (J.Brown). San Francisco challenged the runner was down by contact ruling, and the play was REVERSED. S.Rattler pass short right to A.Kamara to SF 29 for 1 yard (J.Brown, F.Warner). FUMBLES (F.Warner), RECOVERED by F.Warner at SF 32. Turnover flips the possession. Score after play: SF 19, NO 14.
(Shotgun) M.Jones pass deep middle to J.Jennings for 42 yards, TOUCHDOWN. Touchdown swings the leverage immediately. Score after play: SF 26, NO 14.
(Shotgun) M.Jones sacked at SF 44 for -8 yards (C.Rumph). FUMBLES (C.Rumph) [C.Rumph], RECOVERED by D.Davis at SF 47. Turnover flips the possession. Score after play: SF 16, NO 7.
(Shotgun) M.Jones pass short right to C.McCaffrey for 7 yards, TOUCHDOWN. Touchdown swings the leverage immediately. Score after play: SF 16, NO 7.
(Shotgun) S.Rattler pass deep left to J.Johnson for 18 yards, TOUCHDOWN. The Replay Official reviewed the pass completion ruling, and the play was Upheld. The ruling on the field stands. Touchdown swings the leverage immediately. Score after play: SF 9, NO 7.