前半はSteelersが先行。第2QにJaylen Warrenの1ヤードTDで7-0とすると、Billsは前半終了前にMatt Praterの27ヤードFGで3点を返すにとどまり、Pittsburghが7-3で折り返す。
しかし後半開始直後、Buffalo守備が一気に試合を動かす。Joey BosaのストリップサックからChristian Benfordが17ヤードのファンブルリターンTDを決め、Billsが10-7とリードを奪うと、直後にもBenfordがインターセプトを奪い、これに乗じたBuffaloはJosh AllenからKeon Colemanへの1ヤードTDで16-7。第4QにはAllenの8ヤードTDランでさらに突き放した。BillsはJames Cookが144 rushing yards、チームで249 rushing yardsを記録し、Steelersを166 total yardsに抑えた。後半を23-0で支配したBuffaloが26-7で制し、8勝4敗とした。
後半開始直後に17ヤードのファンブルリターンTDを決め、直後の守備でもインターセプトを奪った。7-3で追う展開を一気に逆転させた、Bills守備の主役だった。
(Shotgun) S.Anderson reported in as eligible. A.Rodgers sacked at PIT 17 for -9 yards (J.Bosa). FUMBLES (J.Bosa) [J.Bosa], RECOVERED by C.Benford at PIT 17. C.Benford for 17 yards, TOUCHDOWN. A.Rodgers was injured during the play. Turnover flips the possession. Score after play: BUF 10, PIT 7.
J.Cook left end to BUF 42 for -3 yards (N.Herbig). FUMBLES (N.Herbig), touched at BUF 40, RECOVERED by P.Queen at BUF 39. Turnover flips the possession. Score after play: BUF 0, PIT 0.
(Shotgun) S.Anderson reported in as eligible. M.Rudolph pass deep left intended for D.Washington INTERCEPTED by C.Benford at BUF 44. C.Benford ran ob at BUF 44 for no gain. Drive-ending interception. Score after play: BUF 10, PIT 7.
(Shotgun) J.Allen pass short left to K.Coleman for 1 yard, TOUCHDOWN. PENALTY on Ca.Heyward, Taunting, 15 yards, enforced between downs. Touchdown swings the leverage immediately. Score after play: BUF 16, PIT 7.
(Shotgun) J.Allen right tackle for 8 yards, TOUCHDOWN. Touchdown swings the leverage immediately. Score after play: BUF 23, PIT 7.