49ersはBrock PurdyからJauan Jenningsへの12ヤードTDで先制。両軍FGを交えて10-3とリードして前半を折り返し、さらに第3QにChristian McCaffreyの12ヤードTDで17-3と引き離す。
PanthersはBryce YoungからTetairoa McMillanへの29ヤードTDで一時9点差に迫ったが、第4QのMatt GayのFGで20-9とされ反撃もここまで。San Francisco守備が要所でインターセプトを奪い、Carolinaを9点に封じた。McCaffreyが24回89ヤード1TDで地上を支配。PurdyとYoungがともに複数INTと精彩を欠く中、ランと守備で上回ったSan Franciscoが20-9で制した。
序盤に自陣1ヤードの守備でインターセプトを奪うと、11点リードの4Qにもインターセプト。2本のターンオーバーに絡む活躍でPantersを9点に抑えた守備の中心となった。
J.Curhan reported in as eligible. B.Young pass short right intended for M.Evans INTERCEPTED by J.Brown at SF -8. Touchback. Drive-ending interception. Score after play: CAR 0, SF 7.
B.Purdy pass deep middle intended for R.Pearsall INTERCEPTED by Ja.Horn at CAR 45. Ja.Horn ran ob at SF 33 for 22 yards (C.McKivitz). Drive-ending interception. Score after play: CAR 0, SF 7.
(Shotgun) B.Young pass deep middle to T.McMillan for 29 yards, TOUCHDOWN. Touchdown swings the leverage immediately. Score after play: CAR 9, SF 17.
(Shotgun) B.Purdy pass short middle to J.Jennings for 12 yards, TOUCHDOWN. Touchdown swings the leverage immediately. Score after play: CAR 0, SF 7.
C.McCaffrey left end for 12 yards, TOUCHDOWN. Injury Update: A.Robinson has returned to the game. Touchdown swings the leverage immediately. Score after play: CAR 3, SF 17.